Sally Letter Adebamowo, Donna Spiegelman, Walter C Willett, Kathryn Meters Rexrode, Association between intakes away from magnesium, potassium, and you can calcium supplements and chance of coronary attack: dos cohorts of us women and you can up-to-date meta-analyses, Brand new Western Journal of Systematic Nourishment, Frequency 101, Question 6, , Users 1269–1277,

Conceptual

Background: Possible research towards family members regarding magnesium, potassium, and you can calcium Making Friends dating site consumption which have coronary arrest exposure is actually inconsistent, and all of our knowledge, the outcome off a combined nutrient diet plan score wasn’t looked at.

Objective: We checked-out connections ranging from intakes out-of magnesium, potassium, and you may calcium supplements and you may chance of experience coronary arrest inside 86,149 women in new Nurses’ Health Studies (NHS) I and you may 94,715 ladies in the brand new NHS II.

Design: Inside prospective cohort studies, we calculated Several hours out-of stroke from the quintiles from intake for each and every nutrient as well as a combined diet rating of all step three nutrients that with multivariate Cox proportional chances models. Likewise, we updated meta-analyses towards slimming down consumption of them vitamins and you may risk of coronary attack.

Results: During pursue-up (30 y on the NHS I; 22 y in the NHS II) a total of 3780 event coronary attack times was basically recorded. Pooled multivariate RRs regarding complete stroke for ladies in the higher compared to a minimal quintiles was 0.87 (95% CI: 0.78, 0.97) getting complete magnesium, 0.89 (95% CI: 0.80, 0.99) to have complete potassium, and 0.97 (95% CI: 0.87, step one.09) to possess full calcium supplements intake. Pooled RRs for women throughout the large compared to a minimal quintiles off a mixed mineral eating plan rating was indeed 0.72 (95% CI: 0.65, 0.81) for full stroke, 0.78 (95% CI: 0.66, 0.92) getting ischemic heart attack, and 0.80 (95% CI: 0.61, 1.04) to have hemorrhagic stroke. On current meta-analyses of all prospective training so far, brand new combined RR out-of full coronary attack was 0.87 (95% CI: 0.83, 0.92) to have a hundred-mg/d escalation in magnesium consumption, 0.91 (95% CI: 0.88, 0.94) to have a great 1000-mg/d escalation in potassium intake, and you can 0.98 (95% CI: 0.94, step 1.02) getting a 300-mg/d escalation in calcium consumption.

Conclusions: A combined nutrient eating plan get are inversely for the chance of stroke. High consumption away from magnesium and you can potassium however calcium supplements have been along with notably for the shorter chance of coronary attack in women.

Introduction

Magnesium is a vital nutrient and you will cofactor for >300 enzymatic responses in the human body ( 1). Magnesium ‘s the 2nd extremely-abundant intracellular cation close to potassium ( 2). Calcium supplements is considered the most-numerous mineral in the torso. Such magnesium and you can potassium, calcium supplements is actually vitally employed in cardiovascular attributes ( 3). Large weightloss intakes of each and every ones nutritional elements had been advertised so you can down likelihood of blood pressure levels ( 4– 7), the dominant modifiable coronary attack chance factor. Yet not, not all the prospective knowledge examined new family relations anywhere between losing weight and you may extra consumption of those nutrients and you will threat of coronary arrest in females, and you may efficiency was indeed contradictory. Potential degree when you look at the European countries displayed magnesium consumption, but not consumption from potassium otherwise calcium supplements, was somewhat associated with faster risk of stroke ( 7, 8). In the usa, consumption away from potassium and you will magnesium, but not of calcium, was indeed for the reduced stroke risk in the men ( 9), while calcium supplements and you will potassium intakes, yet not magnesium consumption, was basically of this shorter coronary attack risk in females ( 10). Plus, that studies presented zero complete connection ranging from some of these nutrition and you will chance of coronary attack ( 11).

The potential observational education which were presented failed to tend to be follow-right up past 15 y together with a relatively small number of event coronary attack events, and in extremely studies, the new independent effectation of per mineral intake off capsules and you will heart attack brands was not checked. On this page, we provide evidence into the connection of each mineral consumption out of dieting and drugs having danger of full, ischemic, and you will hemorrhagic incident strokes. Simultaneously, we hypothesized one a blended eating plan score of all 3 nutritional elements could be with the shorter coronary arrest exposure mainly because nutrition can be found along with her from inside the dinners, and you can intakes try strongly correlated. I addressed such tries when you look at the All of us women who was implemented prospectively about dos high cohorts this new Nurses’ Fitness Study (NHS) 5 I and you may II.